Linear MPC for anesthesia process with external predictor

In this paper we present a new model predictive control system for the depth of hypnosis in general anesthesia. The is measured by Bispectral Index Scale signal and controlled through propofol administration. proposed scheme based on an external predictor that, exploiting Wiener structure pharmacokinetic/pharmacodynamic propofol, compensates process nonlinearity increases robustness means additional filter. performance developed evaluated extensive simulation study, which considers inter-patient intra-patient variability applying Monte Carlo technique. obtained results show that methodology effective both induction maintenance phases.